diff --git a/litellm/proxy/_types.py b/litellm/proxy/_types.py
index 33a1e4179f..1b594e20d3 100644
--- a/litellm/proxy/_types.py
+++ b/litellm/proxy/_types.py
@@ -2177,6 +2177,17 @@ class ConfigGeneralSettings(LiteLLMPydanticObjectBase):
             "`statement_cache_size`). Keys here override any default LiteLLM sets."
         ),
     )
+    database_disable_prepared_statements: Optional[bool] = Field(
+        None,
+        description=(
+            "Disable server-side prepared statements by setting Prisma's "
+            "`pgbouncer=true` URL param. Use this for pgbouncer transaction-pooling "
+            "deployments, or to prevent the 'cached plan must not change result "
+            "type' error that pooled connections hit during rolling schema "
+            "migrations. An explicit `pgbouncer` in `database_extra_connection_params` "
+            "takes precedence."
+        ),
+    )
     database_type: Optional[Literal["dynamo_db"]] = Field(
         None, description="to use dynamodb instead of postgres db"
     )
diff --git a/litellm/proxy/proxy_cli.py b/litellm/proxy/proxy_cli.py
index ae831ef1b5..8c3fa95290 100644
--- a/litellm/proxy/proxy_cli.py
+++ b/litellm/proxy/proxy_cli.py
@@ -44,15 +44,19 @@ def _build_db_connection_url_params(
     pool_timeout: Optional[Union[int, float]],
     connect_timeout: Optional[Union[int, float]] = None,
     socket_timeout: Optional[Union[int, float]] = None,
+    disable_prepared_statements: bool = False,
     extra_params: Optional[dict] = None,
 ) -> dict:
     """Build the Prisma DATABASE_URL query params controlling connection pool behavior.
 
     `connect_timeout` / `socket_timeout` map to the Prisma URL params of the same
     name (https://www.prisma.io/docs/orm/overview/databases/postgresql) and are
-    omitted when None so Prisma's defaults apply. `extra_params` is an
-    untyped passthrough — keys it provides win over the named arguments above,
-    so it can be used to override any default we set here.
+    omitted when None so Prisma's defaults apply. `disable_prepared_statements`
+    sets `pgbouncer=true`, which makes Prisma stop using server-side prepared
+    statements (pgbouncer transaction-pool compatible; also sidesteps the
+    "cached plan must not change result type" error during rolling migrations).
+    `extra_params` is an untyped passthrough — keys it provides win over the
+    named arguments above, so it can be used to override any default we set here.
     """
     params: dict = {
         "connection_limit": connection_limit,
@@ -63,6 +67,8 @@ def _build_db_connection_url_params(
         params["connect_timeout"] = connect_timeout
     if socket_timeout is not None:
         params["socket_timeout"] = socket_timeout
+    if disable_prepared_statements:
+        params["pgbouncer"] = "true"
     if extra_params:
         params.update(extra_params)
     return params
@@ -963,6 +969,7 @@ def run_server(  # noqa: PLR0915
         db_connection_timeout: Optional[Union[int, float]] = 60
         db_connect_timeout: Optional[Union[int, float]] = None
         db_socket_timeout: Optional[Union[int, float]] = None
+        db_disable_prepared_statements: bool = False
         db_extra_connection_params: Optional[dict] = None
         general_settings = {}
         ### GET DB TOKEN FOR IAM AUTH ###
@@ -1083,6 +1090,17 @@ def run_server(  # noqa: PLR0915
                 )
             db_connect_timeout = general_settings.get("database_connect_timeout")
             db_socket_timeout = general_settings.get("database_socket_timeout")
+            _disable_prepared_statements = general_settings.get(
+                "database_disable_prepared_statements", False
+            )
+            if isinstance(_disable_prepared_statements, str):
+                from litellm.secret_managers.main import str_to_bool
+
+                db_disable_prepared_statements = (
+                    str_to_bool(_disable_prepared_statements) is True
+                )
+            else:
+                db_disable_prepared_statements = bool(_disable_prepared_statements)
             db_extra_connection_params = general_settings.get(
                 "database_extra_connection_params"
             )
@@ -1130,6 +1148,7 @@ def run_server(  # noqa: PLR0915
                     pool_timeout=db_connection_timeout,
                     connect_timeout=db_connect_timeout,
                     socket_timeout=db_socket_timeout,
+                    disable_prepared_statements=db_disable_prepared_statements,
                     extra_params=db_extra_connection_params,
                 )
                 if os.getenv("DATABASE_URL", None) is not None:
diff --git a/tests/test_litellm/proxy/test_proxy_cli.py b/tests/test_litellm/proxy/test_proxy_cli.py
index 4fb725b7ef..34c88e2fd3 100644
--- a/tests/test_litellm/proxy/test_proxy_cli.py
+++ b/tests/test_litellm/proxy/test_proxy_cli.py
@@ -795,6 +795,127 @@ class TestProxyInitializationHelpers:
             assert appended_params["pgbouncer"] == "true"
             assert appended_params["statement_cache_size"] == 0
 
+    def test_build_db_connection_url_params_disable_prepared_statements(self):
+        from litellm.proxy.proxy_cli import _build_db_connection_url_params
+
+        params = _build_db_connection_url_params(
+            connection_limit=10,
+            pool_timeout=60,
+            disable_prepared_statements=True,
+        )
+        assert params["pgbouncer"] == "true"
+
+    def test_build_db_connection_url_params_no_pgbouncer_by_default(self):
+        from litellm.proxy.proxy_cli import _build_db_connection_url_params
+
+        params = _build_db_connection_url_params(
+            connection_limit=10,
+            pool_timeout=60,
+        )
+        assert "pgbouncer" not in params
+
+    def test_build_db_connection_url_params_extra_pgbouncer_overrides_flag(self):
+        from litellm.proxy.proxy_cli import _build_db_connection_url_params
+
+        params = _build_db_connection_url_params(
+            connection_limit=10,
+            pool_timeout=60,
+            disable_prepared_statements=True,
+            extra_params={"pgbouncer": "false"},
+        )
+        assert params["pgbouncer"] == "false"
+
+    @pytest.mark.parametrize(
+        "config_value, expect_pgbouncer",
+        [
+            (True, True),
+            (False, False),
+            ("true", True),
+            ("false", False),
+            ("not-a-bool", False),
+        ],
+    )
+    @patch("subprocess.run")
+    @patch("atexit.register")
+    @patch("litellm.proxy.db.prisma_client.PrismaManager.setup_database")
+    @patch(
+        "litellm.proxy.db.prisma_client.should_update_prisma_schema", return_value=False
+    )
+    def test_disable_prepared_statements_forwarded_to_url(
+        self,
+        mock_should_update,
+        mock_setup_db,
+        mock_atexit_register,
+        mock_subprocess_run,
+        config_value,
+        expect_pgbouncer,
+    ):
+        from click.testing import CliRunner
+
+        from litellm.proxy.proxy_cli import run_server
+
+        runner = CliRunner()
+        mock_subprocess_run.return_value = MagicMock(returncode=0)
+
+        mock_proxy_module = MagicMock(
+            app=MagicMock(),
+            ProxyConfig=MagicMock(),
+            KeyManagementSettings=MagicMock(),
+            save_worker_config=MagicMock(),
+        )
+        mock_proxy_module.ProxyConfig.return_value.get_config = AsyncMock(
+            return_value={
+                "general_settings": {
+                    "database_url": "postgresql://test:test@localhost:5432/test",
+                    "database_disable_prepared_statements": config_value,
+                }
+            }
+        )
+
+        clean_env = {
+            k: v
+            for k, v in os.environ.items()
+            if k not in ("DATABASE_URL", "DIRECT_URL")
+        }
+
+        with (
+            patch.dict(os.environ, clean_env, clear=True),
+            patch.dict(
+                "sys.modules",
+                {
+                    "proxy_server": mock_proxy_module,
+                    "litellm.proxy.proxy_server": mock_proxy_module,
+                },
+            ),
+            patch(
+                "litellm.proxy.proxy_cli.ProxyInitializationHelpers._get_default_unvicorn_init_args"
+            ) as mock_get_args,
+            patch(
+                "litellm.proxy.proxy_cli.append_query_params",
+                side_effect=lambda url, params: str(url),
+            ) as mock_append_query_params,
+        ):
+            mock_get_args.return_value = {
+                "app": "litellm.proxy.proxy_server:app",
+                "host": "localhost",
+                "port": 8000,
+            }
+
+            result = runner.invoke(
+                run_server,
+                ["--local", "--config", "test-config.yaml", "--skip_server_startup"],
+            )
+
+            assert (
+                result.exit_code == 0
+            ), f"exit_code={result.exit_code}, output={result.output}"
+            mock_append_query_params.assert_called()
+            appended_params = mock_append_query_params.call_args.args[1]
+            if expect_pgbouncer:
+                assert appended_params["pgbouncer"] == "true"
+            else:
+                assert "pgbouncer" not in appended_params
+
     @patch("uvicorn.run")
     @patch("atexit.register")
     @patch("litellm.proxy.db.prisma_client.PrismaManager.setup_database")
diff --git a/ui/litellm-dashboard/src/lib/http/schema.d.ts b/ui/litellm-dashboard/src/lib/http/schema.d.ts
index 203a56f615..8e47081955 100644
--- a/ui/litellm-dashboard/src/lib/http/schema.d.ts
+++ b/ui/litellm-dashboard/src/lib/http/schema.d.ts
@@ -22012,6 +22012,11 @@ export interface components {
              * @default 60
              */
             database_connection_timeout: number | null;
+            /**
+             * Database Disable Prepared Statements
+             * @description Disable server-side prepared statements by setting Prisma's `pgbouncer=true` URL param. Use this for pgbouncer transaction-pooling deployments, or to prevent the 'cached plan must not change result type' error that pooled connections hit during rolling schema migrations. An explicit `pgbouncer` in `database_extra_connection_params` takes precedence.
+             */
+            database_disable_prepared_statements?: boolean | null;
             /**
              * Database Extra Connection Params
              * @description Escape hatch: extra key/value pairs appended verbatim to the Prisma DATABASE_URL / DIRECT_URL query string (e.g. `sslmode`, `pgbouncer`, `statement_cache_size`). Keys here override any default LiteLLM sets.